Protein anti-cancer agent

Details Protein anti-cancer agent Protein anti-cancer agent

C - Chemistry, Metallurgy

12

N

530/13, 195/1.23

C12N 15/31 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) C07K 14/21 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2010256

We have modified PE40 toxin by removing at least two of its four cysteine amino acid residues and have formed hybrid molecules containing modified PE40 linked to a cell recognition protein that can be an antibody, a growth factor, a hormone, a lymphokine, or another polypeptide.cell recognition protein for which a,specific cellular receptor exists. whereby the modified PE40 toxin is directed to cell types having receptors for the cell recognition protein linked to the modified PE40.

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