A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2760564
The present invention provides a composition and prodrug for targeted drug delivery to the central nervous system of a patient. The inventive composition and prodrug include a pharmaceutically acceptable active agent and at least one protein selected from the group consisting of a fimbrial adhesin protein, a membrane protein, and combinations thereof. The inventive compositions and prodrugs of the present invention selectively target the blood-brain barrier and deliver hydrophilic and lipophilic active agents of varying sizes to the central nervous system.
La présente invention porte sur une composition et sur un promédicament pour administration ciblée de médicaments ciblée vers le système nerveux central d'un patient. La présente composition et le présent promédicament comprennent un agent actif pharmaceutiquement acceptable et au moins une protéine choisie dans le groupe constitué par une protéine adhésine de fimbriae, une protéine de membrane et des combinaisons de celles-ci. Les compositions et promédicaments innovants de la présente invention ciblent sélectivement la barrière hémato-encéphalique et administrent des agents actifs hydrophiles et lipophiles de diverses dimensions au système nerveux central.
Lakkaraju Dasaradhi
Patel Kanaiyalal
Puri Navneet
Soni Vishal
Innopharma Llc
Ridout & Maybee Llp
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