Protein-binding methotrexate derivatives, and medicaments...

Details Protein-binding methotrexate derivatives, and medicaments... Protein-binding methotrexate derivatives, and medicaments...

C - Chemistry, Metallurgy

07

K

C07K 5/10 (2006.01) A61K 47/48 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2657476

The invention relates to methotrexate derivatives which contain a protein-binding group and can be enzymatically split in the body such that the active substance or a low-molecular active substance derivative is released. Also disclosed is a method for producing methotrexate derivatives, the use thereof, and medicaments comprising methotrexate derivatives.

La présente invention concerne des dérivés de méthotrexate, qui contiennent un groupe de liaison protéique et sont enzymatiquement clivables dans le corps lors de la libération du principe actif ou d'un dérivé du principe actif de faible poids moléculaire. L'invention concerne également un procédé de production de dérivés de méthotrexate, leur utilisation et des médicaments contenant lesdits dérivés de méthotrexate.

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