Protein c and endothelial protein c receptor polymorphisms...

C - Chemistry – Metallurgy – 07 – H

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Details

C07H 21/00 (2006.01) A61K 45/00 (2006.01) A61P 29/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2559555

The invention provides methods and kits for obtaining a prognosis for a subject having or at risk of developing an inflammatory condition and for identifying subjects having a greater benefit from treatment with an anti- inflammatory agent or an anti-coagulant agent. The method generally comprises determining a protein C and/or EPCR genotype(s) of a subject for a polymorphisms in the these genes, comparing the determined genotype with known genotypes for the polymorphism that correspond with the ability of the subject to recover from the inflammatory condition and identifying subjects based on their prognosis. The invention also provides for methods of identifying potential subjects having an inflammatory condition who are more likely to benefit from treatment with an anti-inflammatory agent or anti-coagulant agent and subsequent to treatment recover from the inflammatory condition. The invention also provides for methods of treating such subjects with an anti- inflammatory agent or anti-coagulant agent based on the subject's genotype.

La présente invention a trait à des procédés et des trousses pour l'obtention d'un pronostic pour un sujet souffrant ou susceptible de développer une condition inflammatoire et pour l'identification de sujets tirant un plus grand bénéfice du traitement avec un agent anti-inflammatoire ou un agent anticoagulant. De manière générale, le procédé comprend la détermination d'un/des génotype(s) du récepteur de la protéine C et/ou de la protéine C endothéliale d'un sujet pour un polymorphisme dans ces gènes, la comparaison du génotype déterminé avec des génotypes connus pour le polymorphisme qui correspond à la capacité du sujet d'être guéri de la condition inflammatoire et l'identification de sujets sur la base de leur pronostic. L'invention a également trait à des procédés pour l'identification de sujets potentiels souffrant d'une conditions inflammatoire qui sont plus susceptibles de bénéficier d'un traitement avec un agent anti-inflammatoire ou un agent anticoagulant et suite au traitement d'être guéris de la condition inflammatoire. L'invention a trait à des procédés de traitement de tels sujets avec un agent anti-inflammatoire ou un a gent anticoagulant basé sur le génotype du sujet.

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