Protein c derivatives

Details Protein c derivatives Protein c derivatives

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 38/48 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2338799

Novel protein C derivatives are described. These polypeptides retain the biological activity of the wild-type human protein C with substantially longer half-lives in human blood. These polypeptides will require either less frequent administration and/or smaller dosage than wild-type human protein C in the treatment of vascular occlusive disorders, hypercoagulable states, thrombotic disorders and disease states predisposing to thrombosis.

L'invention concerne de nouveaux dérivés de protéine C. Ces polypeptides conservent l'activité biologique de la protéine C humaine de phénotype sauvage, avec des demi-vies sensiblement plus longues dans le sang humain. Ces polypeptides nécessitent donc une administration moins fréquente que la protéine C humaine de phénotype sauvage, et/ou un dosage inférieur à celle-ci, pour traiter les troubles vasculaires occlusifs, les états d'hypercoagulabilité, les dysfonctionnements thrombotiques et les états pathologiques prédisposant à la thrombose.

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