Protein c derivatives

Details Protein c derivatives Protein c derivatives

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C12N 9/64 (2006.01) C12N 15/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2391651

Novel human protein C derivatives are described. These derivatives have increased anti-coagulation activity compared to wild-type protein C and retain the biological activity of the wild-type human protein C. These derivatives will require either less frequent administration and/or smaller dosage than wild-type human protein C in the treatment of acute coronary syndromes, vascular occlusive disorders, hypercoagulable states, thrombotic disorders and disease states predisposing to thrombosis.

L'invention concerne de nouveaux dérivés de la protéine C humaine. Ces dérivés présentent une activité d'anticoagulation accrue comparés à la protéine C du type sauvage et maintiennent l'activité biologique de la protéine C du type sauvage. Ces dérivés nécessitent une administration moins fréquente et/ou un dosage moins important que la protéine C de type sauvage dans le traitement de syndromes coronaires aigus, de troubles occlusifs vasculaires, d'états hypercoagulants, de troubles thrombotiques et d'états de santé prédisposant à la thrombose.

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