Protein c derivatives

Details Protein c derivatives Protein c derivatives

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) A61K 38/48 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2400187

Novel human protein C derivatives are described. These derivatives have increased anti-coagulation activity, resistance to serpin inactivation, and increased sensitivity to thrombin activation compared to wild-type protein C and retain the biological activity of the wild-type human protein C. These derivatives will require either less frequent administration and/or smaller dosage than wild-type human protein C in the treatment of acute coronary syndromes, vascular occlusive disorders, hypercoagulable states, thrombotic disorders and disease states predisposing to thrombosis.

L'invention concerne de nouveaux dérivés de la protéine C humaine ayant pour fonction l'augmentation de l'activité anticoagulante, la résistance à l'inactivation de la serpine et la sensibilité à l'activation de la thrombine en comparaison avec la protéine C de type sauvage et le maintien de l'activité biologique de la protéine C humaine de type sauvage. L'avantage qui en découle est que l'administration de ces dérivés est moins fréquente et/ou que le dosage est inférieur à celui requis pour la protéine C humaine de type sauvage dans le traitement des syndromes coronaires aigus, les troubles occlusifs vasculaires, les états hypercoagulables, les troubles thrombotiques et les états enclins à la thrombose.

Affiliated with

Also associated with

Rating

Protein c derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Protein c derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protein c derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1530386