A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 38/37 (2006.01) A61P 7/04 (2006.01) C07K 14/745 (2006.01) C07K 17/08 (2006.01) C12N 9/64 (2006.01) C12N 11/08 (2006.01)
Patent
CA 2748662
The invention is directed to a procoagulant conjugate having an endopeptidase-activatable procoagulant protein moiety and one or more bioprotective moieties, which are conjugated to one another by a linker that is cleaved by an endopeptidase in situ to release the bioprotective moiety. The invention is also directed to therapeutic uses of the procoagulant conjugate and methods of making the conjugate.
La présente invention concerne un conjugué pro-coagulant ayant une fraction protéique pro-coagulante pouvant être activée par une endopeptidase et une ou plusieurs fractions bio-protectrices, qui sont conjuguées les unes aux autres par un lieur qui est clivé par une endopeptidase in situ pour libérer la fraction bio-protectrice. L'invention concerne également les utilisations thérapeutiques du conjugué pro-coagulant et des procédés de fabrication du conjugué.
Mei Baisong
Murphy John E.
Tang Liang
Wang Jun
Bayer Healthcare Llc
Mbm Intellectual Property Law Llp
LandOfFree
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