Protein constructs designed for targeting and lysis of cells

Details Protein constructs designed for targeting and lysis of cells Protein constructs designed for targeting and lysis of cells

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2630771

The invention relates to a protein construct, comprising (i) a targeting moiety that is capable of binding to a target cell, and (ii) an effector immunogenic moiety that is capable of triggering an existing, vaccine-induced or natural, immune response. The protein construct, that is preferably in the form of a heteromultimeric protein, is useful for redirecting an immune response that was pre-existing in a patient, toward an undesired target cell.

L'invention a pour objet une construction protéique, qui consiste (i) en un groupement de ciblage capable de se lier à une cellule cible, et (ii) en une partie effectrice immunogénique capable de déclencher une réponse immunitaire existante, induite par un vaccin ou naturelle. La construction protéique, qui se trouve de préférence sous forme d~une protéine hétéromultimérique, s~utilise pour réacheminer une réponse immunitaire préexistante chez un patient, vers une cellule cible indésirable.

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