Protein crystallization in microfluidic structures

Details Protein crystallization in microfluidic structures Protein crystallization in microfluidic structures

C - Chemistry, Metallurgy

30

B

C30B 29/58 (2006.01) B01L 3/00 (2006.01) B01L 7/00 (2006.01) C30B 7/00 (2006.01) C30B 27/00 (2006.01) C30B 30/08 (2006.01) G01N 25/14 (2006.01) G01N 27/447 (2006.01) B01F 13/00 (2006.01) G01N 35/00 (2006.01)

Patent

CA 2404008

A device for promoting protein crystal growth (PCG) using microfluidic channels. A protein sample and a solvent solution are combined within a microfluidic channel having laminar flow characteristics which forms diffusion zones, providing for a well defined crystallization. Protein crystals can then be harvested from the device. The device is particularly suited for microgravity conditions.

Cette invention concerne un dispositif qui favorise la croissance cristalline de protéines au moyen de canaux microfluidiques. On combine un échantillon de protéine et une solution de solvant au sein d'un canal micorfluidique dont les caractéristiques d'écoulement laminaire forme des zones de diffusion, ce qui assure une cristallisation bien définie. Des cristaux de protéine peuvent être recueillis sur le dispositif. Ce dispositif convient particulièrement bien en conditions de microgravité.

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