C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/102 (2006.01) A61K 39/40 (2006.01) C07K 14/285 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 5/18 (2006.01) C12N 15/62 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2083172
A novel surface exposed protein of Haemophilus influenzae or related Haemophilus species is-described. The protein named protein D is an Ig receptor for human IgD and has an apparent molecular weight of 42,000. Protein D can be detected in all of 116 encapsulated and non-encapsulated isolates of H. influenzae studied. The protein from all strains shows in addition to the same apparent molecular weight immunogenic similarities since protein D from all strains interacts with three different mouse monoclonal antibodies and monoclonal human IgD. A method for purification of protein D is described. Cloning of the protein D gene from H. influenzae in E. coli is described as well as the nucleotide sequence and the deduced amino acid se- quence.
Forsgren Arne
Gowling Lafleur Henderson Llp
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