A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/50 (2006.01)
Patent
CA 2588086
The present invention relates to a virus-like particle (VLP) having a plasma membrane-derived lipid bilayer envelope, said VLP further comprising a viral structural protein, or fragment or derivative thereof, capable of forming an enveloped VLP, a fusiogenic protein and a recombinant target protein; methods for the delivery of recombinant target proteins to cells using said VLP, therapeutic methods using said VLP, compositions and kits comprising said VLP, methods of producing said VLP, and vectors and host cells for producing said VLP are also described.
L'invention concerne une particule de type viral (VLP) qui présente une enveloppe bicouche lipidique de membrane cytoplasmique, et qui comporte une protéine structurelle virale, ou un fragment ou un dérivé de celle-ci, capable de former une VLP enveloppée, une protéine fusiogène et une protéine cible recombinée. Par ailleurs, l'invention concerne des procédés d'administration de protéines cibles recombinées à des cellules au moyen de ladite VLP; des méthodes thérapeutiques faisant intervenir ladite VLP; des compositions et des kits qui contiennent ladite VLP; des procédés de préparation de ladite VLP; ainsi que des vecteurs et des cellules hôtes servant à préparer ladite VLP.
Bcf Llp
Bioactive Protein Delivery Therapeutics
Jensen Steen Lindkaer
LandOfFree
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