Protein demethylases comprising a jmjc domain

Details Protein demethylases comprising a jmjc domain Protein demethylases comprising a jmjc domain

C - Chemistry, Metallurgy

12

Q

C12Q 1/26 (2006.01) C12P 21/00 (2006.01) C12P 21/02 (2006.01) C12N 9/02 (2006.01) G01N 33/58 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2622615

Post-translational modification, including protein methylation, plays an important role in regulating protein function. The present invention provides a novel assay for evaluating demethylase activity and the discovery of a family of protein demethylases comprising a novel demethylase motif.

L'invention concerne le rôle important que joue dans la régulation des fonctions des protéines la modification post-translationnelle, y compris la méthylation des protéines. L'invention porte sur une nouvelle analyse pour évaluer l'activité de déméthylase et sur la découverte d'une famille de protéines déméthylases comprenant un nouveau motif de déméthylase.

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