C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/46 (2006.01) A61K 38/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2513904
The present invention relates to genetic diagnosis and therapy of diseases of the nervous system (NS). More particularly, it relates to methods to induce neural precursor cells (NPCs) and to the identification of a domain that determines the functionality of polypeptides belonging to the atonal family, and its use in therapy for the treatment of deafness, partial hearing loss and vestibular defects due to damage of loss of inner ear hair cells. Alternatively, the domain may be used in the treatment of cancer.
L'invention concerne le pronostic génétique et la thérapie de maladies du système nerveux (SN). Plus particulièrement, l'invention concerne des méthodes permettant d'induire des cellules précurseurs neurales (NPC) et d'identifier un domaine qui détermine la fonctionnalité de polypeptides appartenant à la famille atonale, et son utilisation en thérapie pour le traitement de la surdité, de la perte auditive partielle et de déficiences vestibulaires dues à la détérioration ou à la perte de cellules de poils de l'oreille interne. En variante, ledit domaine peut être utilisé dans le traitement du cancer.
Bassem Hassan
Bossuyt Wouter
Quan Xiao-Jiang
Fetherstonhaugh & Co.
K.u. Leuven Research & Development
Vib Vzw
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