A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01)
Patent
CA 2638811
The present invention provides formulations of proteins comprising a variant Fc region that improve the stability in part by reducing the propensisty of such molecules to rapidly aggregate. The invention provides both liquid and lyophilized formulations either of which can be utilized to generate a high protein concentration liquid suitable for administration to a subject. The invention further provides methods of utilizing the formulations of the present invention for therapeutic or prophylactic treatment of diseases and disorders or for diagnostic purposes.
La présente invention concerne des formulations de protéines comprenant une région Fc variante, ces formulations améliorant la stabilité en partie grâce à une réduction de la propension de ces molécules à une agrégation rapide. L'invention concerne aussi bien des formulations liquides que des formulations lyophilisées, chacune de ces formulations pouvant être utilisée pour générer un liquide à forte concentration en protéines pouvant être administré à un sujet. L'invention concerne en outre des méthodes d'utilisation de ces formulations en traitement thérapeutique ou prophylactique de maladies et de troubles ou à des fins diagnostiques.
Allan Christian
Bishop Steven
Chang Stephen
Leach William
Medimmune Llc
Smart & Biggar
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