Protein formulations containing sorbitol

Details Protein formulations containing sorbitol Protein formulations containing sorbitol

A - Human Necessities

61

K

A61K 9/10 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 47/10 (2006.01)

Patent

CA 2675602

The present invention provides a method for suppressing protein aggregation in a liquid formulation during freeze-thaw by including sorbitol in the liquid formulation. The present invention also provides methods for storing and preparing a liquid formulation containing a protein and sorbitol such that the presence of sorbitol suppresses protein aggregation during freezing and/or thawing.

L'invention concerne un procédé pour supprimer l'agrégation de protéines dans une formulation liquide pendant une congélation-décongélation en incluant du sorbitol dans la formulation liquide. La présente invention concerne également des procédés pour stocker et préparer une formulation liquide contenant une protéine et du sorbitol, de telle sorte que la présence de sorbitol supprime l'agrégation de protéines pendant la congélation et/ou la décongélation.

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