Protein from horn fly saliva that disrupts hemostasis

Details Protein from horn fly saliva that disrupts hemostasis Protein from horn fly saliva that disrupts hemostasis

C - Chemistry, Metallurgy

07

K

C07K 14/81 (2006.01) A61K 38/57 (2006.01) C07K 14/435 (2006.01)

Patent

CA 2546665

Compositions and methods for preventing hematophagous infestation of cattle are provided, directed at isolated proteins that disrupt platelet aggregation. Also provided are nucleotide sequences encoding the proteins. The exemplary haematollogen protein was isolated from the salivary glands of Haematobia irritans. The compositions are useful as veterinary vaccines in prevention of blood-feeding in cattle by the infesting horn fly and are also useful in treatment of thrombosis.

Composition et méthodes servant à empêcher les infections du sang chez le bétail et concernant des protéines isolées interrompant l'agrégation des plaquettes. L'invention concerne également des séquences de nucléotides codant ces protéines. On a isolé ces protéines dans les glandes salivaires de Haematobia irritans. Ces compositions sont utiles sous forme de vaccins vétérinaires afin de prévenir des infections provoquées par la mouche des cornes hématophage et sont également utiles pour traiter la thrombose.

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