A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/165 (2006.01) C07C 233/43 (2006.01)
Patent
CA 2172383
A composition for the upregulation of expression of cell antigens, without inducing shedding, which comprises a protein kinase C activator is provided by this invention. Further provided by this invention is a method of detecting and treating tumor cells comprising contacting tumor cells with an effective amount of a protein kinase C activator for the upregulation of expression of antigens of tumor cells, without inducing antigen shedding, and detecting the presence of said antigen or then further contacting said tumor cells with an effective amount of an antibody directed to said antigen.
Composition de régulation de l'expression d'antigènes cellulaires, n'induisant pas d'élimination, comprenant un activateur de protéine kinase C. Est également décrit un procédé de détection et de traitement de cellules tumorales, consistant à mettre les cellules tumorales en contact avec une quantité efficace d'un activateur de protéine kinase C pour la régulation de l'expression d'antigènes de cellules tumorales, sans induire l'élimination de l'antigène, et à détecter la présence de ce dernier ou à mettre les cellules tumorales en contact avec une quantité efficace d'un anticorps dirigé contre l'antigène.
Fisher Paul B.
Leon Jorge A.
Gowling Lafleur Henderson Llp
The Trustees Of Columbia University In The City Of New York
LandOfFree
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