Protein kinase c inhibition and novel compound balanol

Details Protein kinase c inhibition and novel compound balanol Protein kinase c inhibition and novel compound balanol

C - Chemistry, Metallurgy

07

D

C07D 223/12 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2115994

2115994 9303730 PCTABS00020 Balanol, which is derived from fungi of the genus Verticillium, especially the fungus Verticillium balanoides, is provided. Balanol, when substantially pure, is soluble in dimethyl sulfoxide, water, and methanol; insoluble in ethyl acetate and chloroform; gives a positive color reaction with polymolybdic acid, ninhydrin reagent, and ferric chloride; is negative with Dragendorff's reagent and Iodoplatinate spray; has an Rf value of approximately 0.58 with silica gel thin layer chromatography with n-butanol/acetic acid/water at a ratio of 4:1:1 respectively; and has a molecular weight of approximately 550. Compounds of the invention are useful for inhibiting protein kinase C and treating conditions related to, or affected by inhibition of protein kinase C, particularly cancer tumors, inflammatory disease, reperfusion injury, and cardiac dysfunctions related to reperfusion injury.

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