Protein kinase c inhibitors

Details Protein kinase c inhibitors Protein kinase c inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/14 (2006.01) A61K 31/4045 (2006.01)

Patent

CA 2193703

The present invention discloses compounds of Formula I: (see formula (I) that are highly isozyme selective, protein kinase C beta-I and beta-2 isozyme inhibitors. These compounds are 3,4-di-(3'(1'- substituted)-indolyl]-1H-pyrrol-2,5-diones, which can be more commonly described as 3,4-bis(3'-indolyl) maleimides. Also, as isozyme selective inhibitors of the beta-I and beta-2 isozymes, the compounds are therapeutically useful in treating conditions associated with diabetes mellitus and its complications, as well as other disease states associated with an elevation of these isozymes.

L'invention concerne des composés qui constituent des inhibiteurs des isozymes bêta-1 et bêta-2 de la protéine kinase C hautement sélectifs pour les isozymes. Ces composés sont des 3,4-di[3'-indolyl(substitué en 1')]1H-pyrrol-2,5-diones, qui peuvent être plus généralement décrits comme des 3,4-bis(3'-indolyl)maléimides. Par ailleurs, en tant qu'inhibiteurs des isozymes bêta-1 et bêta-2, ces composés sont thérapeutiquement utiles pour traiter des états associés au diabète sucré et ses complications, ainsi que d'autres maladies associées à une élévation du nombre de ces isozymes.

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