Protein kinase c inhibitors

Details Protein kinase c inhibitors Protein kinase c inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/22 (2006.01) A61K 31/40 (2006.01) C07C 43/174 (2006.01) C07C 43/178 (2006.01) C07D 498/22 (2006.01) C07D 513/22 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2216535

This invention provides novel bis-indolemaleimide macrocycle derivatives of formula (I). The invention further provides the preparation, pharmaceutical formulations and the methods of use for inhibiting Protein Kinase C in mammals.

L'invention décrit de nouveaux dérivés macrocycliques de bis-indolémaléimide représenté par la formule générale (I). L'invention décrit également la préparation, des formulations pharmaceutiques et les procédures d'utilisation permettant l'inhibition de la protéine kinase C chez les mammifères.

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