G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) A61K 31/00 (2006.01) A61K 31/7105 (2006.01) A61K 38/00 (2006.01) C12N 15/11 (2006.01) C12Q 1/48 (2006.01)
Patent
CA 2525012
The present invention is based on the discovery that .zeta.PKC expression is increased in the tissues of arthritis patients as compared to normal individuals. Accordingly, the present invention provides methods of diagnosing, prognosing, and monitoring the course of arthritis in a patient based on increased .zeta.PKC gene expression in arthritic tissue. The present invention further provides compounds that inhibit the expression of .zeta.PKC for use as remedies in the treatment of arthritis, including, but not limited to, inhibitory polynucleotides and polypeptides, small molecules, and peptide inhibitors. In addition, the present invention provides pharmaceutical formulations and routes of administration for such remedies, as well as methods for assessing their efficacy.
Cette invention se base sur la découverte selon laquelle l'expression de .zeta.PKC augmente dans les tissus de patients souffrant d'arthrite par rapport aux tissus de sujets normaux. Ainsi, cette invention propose des procédés de diagnostic, de pronostic et de suivi de l'évolution de l'arthrite chez un patient, sur la base de l'augmentation de l'expression du gène de .zeta.PKC dans les tissus arthritiques. Cette invention propose en outre des composés qui inhibent l'expression de la .zeta.PKC, en vue de leur utilisation comme remèdes dans le traitement de l'arthrite, ces composés pouvant être notamment des polynucléotides et des polypeptides à effet inhibiteur, des petites molécules et des inhibiteurs peptidiques. Cette invention concerne en outre des formulations pharmaceutiques et des voies d'administration de ces remèdes, ainsi que des procédés pour évalue leur efficacité.
Arai Maya
Collins-Racie Lisa A.
Lavallie Edward R.
Torys Llp
Wyeth
LandOfFree
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