Protein kinase inhibitors

Details Protein kinase inhibitors Protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) A61P 43/00 (2006.01) C12N 9/99 (2006.01)

Patent

CA 2518743

The Pyrazolo[1,5-a]pyrimidine derivatives represented by formula I and their pharmaceutically acceptable salts exhibit excellent kinase inhibiting activity. Drugs comprising the compounds as effective ingredients are therefore expected to be useful as therapeutic or prophylactic agents for a protein kinase mediated disorder in which kinase is implicated, such as inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth.

Les dérivés de pyrazolo[1,5-a]pyrimidine de cette invention, représentés par la formule (I) et leurs sels acceptables d'un point de vue pharmaceutique, présentent une excellente activité inhibitrice de la protéine kinase. Les médicaments comprenant les composés comme ingrédients efficaces s'avèrent ainsi être utiles comme agents thérapeutiques ou prophylactiques dans une maladie induite par la protéine kinase dans laquelle la kinase est impliquée, telle qu'une maladie inflammatoire, une maladie auto-immune, la destruction osseuse, le cancer et/ou la croissance tumorale.

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