Protein kinase inhibitors

Details Protein kinase inhibitors Protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 239/42 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) A61P 35/00 (2006.01) C07D 213/74 (2006.01) C07D 239/47 (2006.01) C07D 239/48 (2006.01) C07D 239/52 (2006.01)

Patent

CA 2626479

The invention provides disubtituted pyrimidine or pyridine compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Lck, IR, IGF-IR, JNKl , Flt3, Fes, EFGR (Her-1, erbB-1) , cSRC, CDKl/cyclinB, c-RAF, BTK, Bmx, AxI, Aurora-A, AbI, BCR-AbI, TrkB, Tie2, Syk, SGK, SAPK2a, Rskl and Met kinases.

La présente invention concerne une nouvelle classe de composés, des compositions pharmaceutiques comprenant lesdits composés ainsi que des procédés d~utilisation desdits composés dans le but de traiter ou de prévenir des troubles ou maladies associés à une activité anormale ou incontrôlée de kinases ; les troubles ou maladies concernés sont en particulier ceux impliquant l~activation anormale des kinases des protéines Lck, IR, IGF-1R, JNK1 , Flt3, Fes, EFGR (Her-1, erbB-1), cSRC, CDK1/cyclinB, c-RAF, BTK, Bmx, Axl, Aurora-A, Abl, BCR-Abl, TrkB, Tie2, Syk, SGK, SAPK2a, Rsk1 et Met.

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