Protein kinase inhibitors

Details Protein kinase inhibitors Protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2604284

Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the structure (I) including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, X, Z, L2 and w are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

L'invention concerne des inhibiteurs des protéines kinases utilisés dans le traitement de maladies et d'états pathologiques déclenchés par les protéines kinases, tels que le cancer. Les composés de l'invention contiennent des stéréoisomères, des promédicaments ainsi que des sels pharmaceutiquement acceptables de ceux-ci, et sont représentés par la formule (I), dans laquelle R1, R2, R3, X, Z, L2 et w sont tels que définis dans la description. Par ailleurs, l'invention concerne des compositions qui contiennent un composé de l'invention, ainsi que des procédés d'utilisation de celles-ci.

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