Protein kinase inhibitors

Details Protein kinase inhibitors Protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 217/24 (2006.01) A61K 31/472 (2006.01) C07D 217/02 (2006.01) C07D 217/22 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2409597

Novel isoquinoline derivatives which are useful as inhibitors of protein kinases for experimental, medical, and drug design purposes are disclosed. Preferred compounds which are specific inhibitors of protein kinase B are also disclosed. Furthermore, pharmaceutical compositions comprising these protein kinase inhibitors, and methods of using such compositions for treatment and diagnosis of cancers, diabetes, cardiovascular pathologies, hemorrhagic shock, obesity, inflammatory diseases, diseases of the central nervous system, and autoimmune disease, are disclosed.

L'invention concerne des nouveaux dérivés d'isoquinoline qui sont utiles en tant qu'inhibiteurs des protéines kinases dans des applications expérimentales, médicales et de conception de médicaments. L'invention concerne également des composés préférés qui sont des inhibiteurs spécifiques de la protéine kinase B. L'invention concerne en outre des compositions pharmaceutiques comprenant ces inhibiteurs de protéine kinase, et des méthodes d'utilisation de ces compositions dans le traitement et le diagnostic des cancers, du diabète, des pathologies cardio-vasculaires, du choc hémorragique, de l'obésité, des maladies inflammatoires, des maladies du système nerveux central et des maladies auto-immunes.

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