Protein kinase inhibitors and methods for using thereof

Details Protein kinase inhibitors and methods for using thereof Protein kinase inhibitors and methods for using thereof

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2690653

The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of Alk, Ab1, Aurora-A, B-Raf, C-Raf, Bcr-Abl, BRK, Blk, Bmx, BTK, C-Kit, CSK, C-Src, EphB1, EphB2, EphB4, FLT1, Fms, Flt3, Fyn, FRK3, JAK2, KDR, Lck, Lyn, PDGFR.alpha., PDGFR.beta., PKC.alpha., SAPK2.alpha., Src, SIK, Syk, Tie2 and TrkB kinases.

La présente invention concerne des composés et leurs compositions pharmaceutiques, qui se révèlent utiles en tant qu'inhibiteurs de protéine kinase, ainsi que des procédés d'utilisation de tels composés pour traiter, améliorer ou prévenir une pathologie associée à une activité kinase anormale ou déréglée. Selon certains modes de réalisations, la présente invention concerne des procédés d'utilisation desdits composés pour traiter, améliorer ou prévenir des maladies ou des troubles qui impliquent une activation anormale des kinases Alk, Abl, Aurora-A, B-Raf, C-Raf, Bcr-Abl, BRK, Blk, Bmx, BTK, C-Kit, CSK, C-Src, EphB1, EphB2, EphB4, FLT1, Fms, Flt3, Fyn, FRK3, JAK2, KDR, Lck, Lyn, PDGFRa, PDGFRß, PKCa, SAPK2a, Src, SIK, Syk, Tie2 et TrkB.

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