Protein kinase inhibitors and related compounds combined...

Details Protein kinase inhibitors and related compounds combined... Protein kinase inhibitors and related compounds combined...

C - Chemistry, Metallurgy

07

D

C07D 498/22 (2006.01) A61K 31/55 (2006.01) C07H 9/06 (2006.01) C07H 19/23 (2006.01)

Patent

CA 2140653

This invention describes both known and novel compounds, some of which are protein kinase inhibitors, that may be com- bined with taxol type compounds. The combination of disclosed compounds plus taxol type compounds exhibits powerful syner- gistic effects and the combinations are useful in the treatment of cancer, The novel compounds and their synthesis are described. A compound of formula (I), above, is described wherein R1-R8 represent various substituents.

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