Protein kinase inhibitors and uses thereof

Details Protein kinase inhibitors and uses thereof Protein kinase inhibitors and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 239/42 (2006.01) A61K 31/44 (2006.01) A61K 31/4418 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 19/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 213/74 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2495386

Described herein are compounds that are useful as protein kinase inhibitors having the formulae (I) and (V) or a pharmaceutically acceptable salt thereof, wherein Ring B, Z1, Z2U, T, m, n, p, Q, Q', R1, R2, Rx, R3, and R6 are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including stroke, inflammatory disorders, autoimmune diseases such as SLE lupus and psoriasis, proliferative disorders such as cancer, and conditions associated with organ transplantation.

L'invention concerne des composés utiles en tant qu'inhibiteurs de la protéine kinase représentés par les formules (I) et (V) ou un sel pharmaceutiquement acceptable desdits composés. Dans lesdites formules, le noyau B, Z?1¿, Z?2 ¿U,? ¿T, m, n, p, Q, Q', R?1¿, R?2¿, R?x¿, R?3¿ et R?6¿ sont tels que définis dans le descriptif. Ces composés, ainsi que leurs compositions pharmaceutiquement acceptables, sont utiles pour traiter ou diminuer la sévérité de différents troubles, notamment l'apoplexie, les troubles inflammatoires, les maladies auto-immunes, telles que le lupus érythémateux systématique et le psoriasis, les troubles prolifératifs, tels que le cancer, et les maladies associées à la transplantation d'organes.

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