Protein kinase modulators and methods of use

Details Protein kinase modulators and methods of use Protein kinase modulators and methods of use

A - Human Necessities

61

K

A61K 31/4965 (2006.01) A61K 31/497 (2006.01) A61K 31/55 (2006.01) A61P 35/00 (2006.01) C07D 241/26 (2006.01) C07D 241/28 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/10 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 413/04 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2484209

This invention relates to compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion, and to pharmaceutical compositions containing such compounds. Even more specifically, the invention relates to compounds that inhibit, regulate and/or modulate kinases, particularly Checkpoint Kinases, even more particularly Checkpoint Kinase 1, or Chk1. Methods of therapeutically or prophylactically using the compounds and compositions to treat kinase-dependent diseases and conditions are also an aspect of the invention, and include methods of treating cancer, as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, by administering effective amounts of such compounds.

L'invention se rapporte à des composés modulant l'activité enzymatique de la protéine kinase, pour la modulation d'activités cellulaires, telles que prolifération, différenciation, mort cellulaire programmée, migration et chimio-invasion, ainsi qu'à des compositions pharmaceutiques contenant de tels composés. Plus spécifiquement, l'invention se rapporte à des composés qui inhibent, régulent et/ou modulent des kinases, en particulier des kinases de contrôle et, plus particulièrement, une kinase de contrôle 1 ou Chk1. L'invention englobe également, suivant un autre aspect, des procédés d'utilisation, sur le plan thérapeutique ou prophylactique, des composés et des compositions pour le traitement de maladies et d'états dépendants de la kinase, ainsi que des procédés de traitement du cancer, et d'autres états associés à une angiogenèse et/ou à une prolifération cellulaire indésirable, par administration de quantités efficaces de tels composés.

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