Protein kinase signalling

Details Protein kinase signalling Protein kinase signalling

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61K 38/43 (2006.01) A61P 11/06 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 14/52 (2006.01) C07K 14/71 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2436610

The present invention provides a method of selecting or designing a compound for the ability to regulate JAK activity. The method comprises assessing the ability of the compound to modulate the interaction of the pseudo-substrate loop (PSL) with the kinase like domain (KLD) of JAK. In addition the present invention provides compounds which inhibit JAK and methods of treatment of JAK- associated disease states.

La présente invention concerne un procédé de sélection ou de production d'un composé permettant la régulation de l'activité de la kinase de Janus (JAK). Le procédé comporte l'évaluation de la capacité du composé de moduler de l'interaction de la boucle de pseudo-substrat (PSL) avec le domaine de type kinase de la kinase de Janus (JAK). En outre, la présente invention concerne des composés permettant l'inhibition de la kinase de Janus (JAK) et des procédés de traitement de conditions pathologiques associées à la kinase de Janus (JAK).

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