C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/129, 167/139
C07D 311/82 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 1/107 (2006.01) G01N 33/532 (2006.01) G01N 33/533 (2006.01)
Patent
CA 1330145
PROTEIN LABEL AND DRUG DELIVERY SYSTEM ABSTRACT OF THE DISCLOSURE A bridging molecule carrying a drug, or a label such as a fluorophore, which adds across disulfide bonds of molecules, particularly proteins, and methods of manufacturing and using the bridging molecules, are disclosed. The bridging molecule is reactive with sulfhydryl groups formed by the reduction of disulfide bonds of the protein. The functional groups of the bridging molecules are typically -SH groups.
522594
Edidin Michael
Komoriya Akira
Packard Beverly
G. Ronald Bell & Associates
The Johns Hopkins University
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