Protein labelling

Details Protein labelling Protein labelling

C - Chemistry, Metallurgy

07

D

260/302, 167/47,

C07D 207/46 (2006.01) A61K 47/48 (2006.01) C07D 207/404 (2006.01) C07D 277/56 (2006.01) C07D 401/02 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 417/12 (2006.01) G01N 33/534 (2006.01)

Patent

CA 2010800

Bifunctional aromatic compounds which are capable of linking metal ions to biologically useful molecules. The bifunctional compounds are characterized as having a hydrazine or hydrazide group and a protein reactive group. The hydrazine or hydrazide group may be protected as a lower alkyl hydrazone. Conjugates of the bifunctional compounds with macromolecules are also described and labelled macromolecules comprised of the conjugates and metal ions are provided. Additionally, a method is provided for forming a labelled macromolecule by reacting a conjugate with a metal species. The compounds and method of this invention are particularly useful in the fields of biology and medicine for imaging and/or therapy.

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