Protein ligands for nkg2d and ul16 receptors and uses thereof

Details Protein ligands for nkg2d and ul16 receptors and uses thereof Protein ligands for nkg2d and ul16 receptors and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/48 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2556861

A novel member of the RAET1/ULBP family of proteins (RAET1G) is identified and characterised and shown to bind the UL16 and NKG2D receptors with high affinity. RAET1G exhibits restricted expression in normal tissues but exhibits high levels of expression in tumours and may be differentially spliced in cancer cells to produce a soluble protein. RAET1G is also up-regulated in inflammatory diseases such as coeliac disease. RAET1G may be used as a novel marker for disease conditions including cancer conditions and inflammatory diseases.

La présente invention concerne un nouveau membre de la famille RAET1/ULBP de protéines (RAET1G) identifié et caractérisé, qui se lie aux récepteurs UL16 et NKG2D avec une grande affinité. RAET1G présente une expression limitée dans des tissus normaux, mais présente de hauts niveaux d'expression dans des tumeurs et peut être épissé lors de la différenciation dans des cellules cancéreuses afin de produire une protéine soluble. RAET1G est également régulé à la hausse dans le cas de maladies inflammatoires telles qu'une maladie coeliaque. RAET1G peut être utilisé en tant que nouveau marqueur pour des pathologies telles que des pathologies cancéreuses et des maladies inflammatoires.

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