Protein localization assays for toxicity and antidotes thereto

Details Protein localization assays for toxicity and antidotes thereto Protein localization assays for toxicity and antidotes thereto

G - Physics

01

N

G01N 33/50 (2006.01)

Patent

CA 2375155

Intracellular translocation of proteins, particularly protein kinase C (PKC) isoenzymes, provides a surrogate test system for determining toxicity of candidate compounds. The profile of translocation with respect to at least one and preferably two or more signal transduction proteins can be correlated with that of known toxins. In addition, databases of such profiles with respect to toxins of various types provide a useful set of standards for evaluating toxicity of candidate compounds. Moreover, to the extent that a toxin's profile mimics that found in a diseased state, the toxin can be used to construct screens for compounds alleviating the disease.

L'invention concerne la translocation intracellulaire de protéines, particulièrement les isoenzymes de la protéine kinase C (PKC), fournissant un système de dosage de remplacement permettant de déterminer la toxicité de composés candidats. Le profil de translocation par rapport à au moins un ou de préférence deux ou plusieurs protéines de transduction de signal peut être mis en corrélation avec celui de toxines connues. En outre, les bases de données telles que les profils par rapport aux toxines de différents types fournissent un groupe utile de normes d'évaluation de la toxicité de composés candidats. Mais ce n'est pas tout, la toxine peut servir à construire des cribles pour des composés soulageant la maladie dans la mesure où le profil de la toxine est analogue à celui trouvé dans un état malade.

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