Protein markers for pharmaceuticals and related toxicity

Details Protein markers for pharmaceuticals and related toxicity Protein markers for pharmaceuticals and related toxicity

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) A61K 38/00 (2006.01) A61K 38/51 (2006.01) A61K 38/54 (2006.01) A61K 45/00 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01) A61P 43/00 (2006.01) C07H 21/04 (2006.01) C07K 1/00 (2006.01) C07K 16/00 (2006.01) C12N 15/09 (2006.01) C12Q 1/02 (2006.01) C12Q 1/26 (2006.01) C12Q 1/30 (2006.01) C12Q 1/32 (2006.01) C12Q 1/34 (2006.01) C12Q 1/37 (2006.01) C12Q 1/40 (2006.01) C12Q 1/42 (2006.01) C12Q 1/44 (2006.01) C12Q 1/46 (2006.01) C12Q 1/48 (2006.01) C12Q 1/50 (2006.01) C12Q 1/52 (2006.01) C12Q

Patent

CA 2410158

Protein markers of toxicity and efficacy for drugs are determined. For example, methods and reagents are disclosed for determining whether a patient receiving an antilipemic drug, especially a statin or HMGCoA reductase inhibiting drug, is experiencing drug efficacy and/or toxicity. Individual susceptibility is also determined prior to treatment. Also, drug discovery of similar acting candidates and their likelihood of being toxic or effective is determined by analysis of all proteins in a sample simultaneously by 2- dimensional gel elecrotphoresis.

L'invention concerne des protéines-marqueurs de toxicité et d'efficacité pour des médicaments. L'invention concerne, par exemple, des procédés et des réactifs permettant de déterminer l'efficacité et/ou la toxicité d'un médicament hypolipémiant, notamment un médicament inhibant la statine ou la HMG CoA réductase, chez un patient auquel on a administré un tel médicament. On détermine également la sensibilité individuelle avant le traitement. On détermine également la découverte médicamenteuse de candidats agissant de manière similaire et leur potentiel d'efficacité ou de toxicité en analysant, de manière simultanée, toutes les protéines dans un échantillon, au moyen d'une électrophorèse 2-dimensionnelle sur gel.

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