Protein matrix materials, devices and methods of making and...

Details Protein matrix materials, devices and methods of making and... Protein matrix materials, devices and methods of making and...

A - Human Necessities

61

K

A61K 9/10 (2006.01) A61K 9/22 (2006.01) A61K 9/70 (2006.01) A61K 47/42 (2006.01)

Patent

CA 2401385

The present invention relates to protein matrix materials and devices and the methods of making and using protein matrix materials and devices. More specifically the present invention relates to protein matrix materials and devices that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, encapsulated or coated stent devices, vessels, tubular grafts, vascular grafts, wound healing devices including protein matrix suture material and meshes, skin/bone/tissue grafts, biocompatible electricity conducting matrices, clear protein matrices, protein matrix adhesion prevention barriers, cell scaffolding and other biocompatible protein matrix devices. Furthermore, the present invention relates to protein matrix materials and devices made by forming a film comprising one or more biodegradable protein materials, one or more biocompatible solvents and optionally one or more pharmacologically active agents. The film is then partially dried, rolled or otherwise shaped, and then compressed to form the desired protein matrix device.

L'invention concerne des matériaux de matrice protéique, des dispositifs correspondants, ainsi que des procédés pour leur production et leur utilisation. Elle concerne plus particulièrement des matériaux de matrice protéique et des dispositifs correspondants pouvant être utilisés pour diverses applications médicales comprenant, de manière non exhaustive, des dispositifs d'administration de médicaments pour la libération contrôlée de principes actifs pharmacologiques, des dispositifs de type stents encapsulés ou enrobés, des vaisseaux, des greffes tubulaires, des greffes vasculaires, des dispositifs de cicatrisation comprenant le matériau de suture et des maillages à base de matrice protéique, des greffes de peau/d'os/de tissus, des matrices électroconductrices biocompatibles, des matrices de protéines transparentes, des barrières servant à empêcher l'adhérence de la matrice protéique, des squelettes cellulaires et autres dispositifs à matrices protéiques biocompatibles. L'invention concerne en outre des matériaux de matrice protéique et des dispositifs correspondants obtenus par formation d'un film comprenant un ou plusieurs matériaux de matrice protéique biodégradables, un ou plusieurs solvants biodégradables et éventuellement un ou plusieurs principes actifs pharmacologiques. Ce film est ensuite partiellement séché, enroulé ou façonné d'une autre manière, puis comprimé pour former le dispositif à matrice protéique voulu.

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