Protein mixtures to induce therapeutic angiogenesis

Details Protein mixtures to induce therapeutic angiogenesis Protein mixtures to induce therapeutic angiogenesis

C - Chemistry, Metallurgy

07

K

C07K 14/51 (2006.01) A61K 38/18 (2006.01) C07K 14/515 (2006.01)

Patent

CA 2330665

An angiogenic factor comprising a mixture of proteins derived from bone. The angiogenic protein mixture is produced by a series of steps that allow the proteins to be kept in solution. The angiogenic mixture of bone proteins is produced by a multi-step process that includes at least one ultrafiltration step, an anion exchange chromatography step, a cation exchange chromatography step and a high performance liquid chromatography (HPLC) purification step.

L'invention concerne un facteur angiogénique comprenant un mélange de protéines dérivées de l'os. Ce mélange de protéines angiogénique est produit selon une série d'étapes permettant aux protéines d'être maintenues en solution. Le mélange angiogénique de protéines osseuses est produit selon un procédé à plusieurs étapes qui comprend au moins une étape d'ultrafiltration, une étape de chromatographie par échange d'anions, une étape de chromatographie par échange de cations et une étape de purification par chromatographie liquide à haute performance.

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