Protein modification

C - Chemistry – Metallurgy – 12 – P

Patent

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Details

C12P 21/00 (2006.01) A61K 38/17 (2006.01) A61K 38/55 (2006.01) C07K 14/81 (2006.01) C12N 9/10 (2006.01) C12P 19/00 (2006.01) C12P 19/44 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2502539

The present invention relates to a method for changing the half-life of a glycosylated compound by the modification of its O-linked carbohydrates. This modification is preferably carried out enzymatically and aimed at extending the half-life of the com~pound. Both in vivo and in vitro modification protocols may be used.

L'invention concerne un procédé de changement de la demi-vie d'un composé glycosylé par la modification de ses glucides à liaison O. Cette modification s'effectue de préférence de manière enzymatique et vise à prolonger la demi-vie du composé. Des protocoles de modification in vivo et in vitro peuvent être utilisés.

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