C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/00 (2006.01) A61K 38/17 (2006.01) A61K 38/55 (2006.01) C07K 14/81 (2006.01) C12N 9/10 (2006.01) C12P 19/00 (2006.01) C12P 19/44 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2502539
The present invention relates to a method for changing the half-life of a glycosylated compound by the modification of its O-linked carbohydrates. This modification is preferably carried out enzymatically and aimed at extending the half-life of the com~pound. Both in vivo and in vitro modification protocols may be used.
L'invention concerne un procédé de changement de la demi-vie d'un composé glycosylé par la modification de ses glucides à liaison O. Cette modification s'effectue de préférence de manière enzymatique et vise à prolonger la demi-vie du composé. Des protocoles de modification in vivo et in vitro peuvent être utilisés.
Mannesse Maurice
Pieper Frank
Van Berkel Patrick
Gowling Lafleur Henderson Llp
Pharming Intellectual Property B.v.
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