C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/00 (2006.01) C07K 2/00 (2006.01) C07K 9/00 (2006.01) C07K 14/55 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2155762
Transglutaminase is allowed to act upon both a physiologically active protein (inclusive of a fused protein thereof with a peptide through acid amide bonding) and an amino group donor containing the polyethylene glycol, polysaccharide, polyamino acid or branched type sugar derivative moiety, whereby the physiologically active protein is modified without spoiling its inherent physiological activities, and may be improved in its qualification as a drug.
On améliore la possibilité d'adaptation en médicament d'une protéine physiologiquement active (incluant une protéine fusionnée renfermant celle-ci et un peptide lié à celle-ci par une liaison amide) en modifiant la protéine par l'action de la transglutaminase sur la protéine et d'un donneur de groupe amino comportant une partie dérivée de polyéthylène glycol, polysaccharide, acide polyaminé ou saccharide ramifié, sans causer d'altération à son activité physiologique intrinsèque.
Ikeda Masahiro
Sakagami Masahiro
Sato Haruya
Suzuki Kokichi
Taniguchi Makoto
Drug Delivery System Institute Ltd.
Ridout & Maybee Llp
LandOfFree
Protein modification method does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Protein modification method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protein modification method will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1564844