Protein modifier production inhibitor

Details Protein modifier production inhibitor Protein modifier production inhibitor

C - Chemistry, Metallurgy

07

D

C07D 231/22 (2006.01) A61K 31/4152 (2006.01) A61K 31/4155 (2006.01) A61K 31/416 (2006.01) A61K 31/4162 (2006.01) A61K 31/427 (2006.01) A61K 31/433 (2006.01) A61K 31/4355 (2006.01) A61K 31/4439 (2006.01) A61K 31/4709 (2006.01) A61P 3/10 (2006.01) A61P 7/08 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 13/00 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 27/02 (2006.01) A61P 27/12 (2006.01) A61P 29/00 (2006.

Patent

CA 2547887

To provide a inhibitor of protein modification products formation capable of inhibiting of vitamin B6 deficiency disease as a side effect, especially a renal protective agent. [MEANS FOR SOLVING PROBLEMS) There is provided a use, as an active ingredient, of any of free or salt-form compounds of either of the formulae: (I) (II) [wherein R1 is substituted or unsubstituted aromatic ring; and each of R2, R3 and R4 is a hydrogen atom or monovalent organic group, or alternatively R2 and R3 cooperate to form a condensed ring or R3 and R4 cooperate to represent a divalent organic group, provided that R3 and R4 are not simulataneously hydrogen atoms].

L'invention concerne un inhibiteur de production de modificateurs de protéines pouvant inhiber la carence en vitamine B6 en tant qu'effet secondaire, notamment un agent de protection rénale. On décrit l'utilisation, en tant qu'ingrédient actif de l'un quelconque des composés libre ou de forme saline de formule (I) ou de formule (II), dans lesquelles R1 est un noyau aromatique substitué ou insubstitué; et chacun des éléments R2, R3 et R4 est un atome d'hydrogène ou un groupe organique monovalent; R2 et R3 coopèrent pour former un noyau condensé; ou bien R3 et R4 coopèrent pour représenter un groupe organique divalent, à condition que R3 et R4 ne soient pas simultanément des atomes d'hydrogène.

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