Protein modifying enzyme

Details Protein modifying enzyme Protein modifying enzyme

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) C12N 9/10 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2181563

The present invention relates, in general, to a protein prenyltransferase and, in particular, to protein geranylgeranyltransferase (GGTase- I) and to a nucleic acid sequence encoding same. The invention also relates to methods of producing GGTase-I and geranylgeranyl modified polypeptides. The invention further relates to a method of screening compounds for the ability to alter GGTase-I activity.

L'invention porte en général sur une prényltransférase protéique et en particulier sur la géranylgéranyltransférase protéique (GGTase-I) et la séquence d'acide nucléique codant pour elle. L'invention porte également sur les méthodes d'obtention de polypeptides modifiés par la GGTase-I et le géranylgéranyle ainsi que sur une méthode de sélection de composés quant à leur capacité de modification de l'activité de la GGTase-I.

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