Protein nectin-3

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07K 14/78 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2373422

This application provides a novel protein, nectin-3 having an amino acid sequence of any of SEQ ID NO: 2, 4 or 6, which belongs to a nectin protein family participating in cell-cell adhesion. It also provides a polynucleotide that codes for the nectin-3 and has a base sequence of any of SEQ ID NO: 1, 3 or 5; a recombinant vector having the polynucleotide; and an antibody against the protein nectin- 3. The protein nectin-3 provides important information for clarifying all aspects of the molecular mechanism in cell-cell binding systems, and, in addition, it leads to the possibility of clarifying the mechanism of, for example, humectation and metastasis of carcinoma, and is expected to be applicable to diagnosis of carcinoma for its malignancy and to a method for treating cases with carcinoma and also to development of medicines for carcinoma.

L'invention concerne des protéines du type nectine 3 qui possèdent des séquences d'acides aminés représentées par SEQ ID NOS :2, 4 et 6, qui sont des nouvelles protéines appartenant à la famille des protéines de type nectine, participant à l'adhésion entre les cellules ; des polynucléotides codant pour lesdites protéines du type nectine-3 et dont les séquences de base sont sélectivement représentées par SEQ ID NOS : 1, 3 et 5 ; des vecteurs de recombinaison possédant lesdits nucléotides ; et des anticorps dirigés contre lesdites protéines du type nectine 3. Les protéines du type nectine 3 fournissent non seulement des informations importantes pour l'éclaircissement du mécanisme moléculaire intégral de l'adhésion cellulaire mais peuvent également apporter des éclaircissements sur, par exemple, les mécanismes d'infiltration et de formation de métastases du cancer, et sont donc utiles dans le diagnostic de la malignité du cancer, dans la mise au point, entre autres, de méthodes de prévention et de traitement dudit cancer et de remèdes contre ce dernier.

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