Protein oligomer compositions comprising endostatin protein...

Details Protein oligomer compositions comprising endostatin protein... Protein oligomer compositions comprising endostatin protein...

C - Chemistry, Metallurgy

07

K

C07K 14/78 (2006.01) A61K 38/39 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2331370

Protein oligomer compositions comprising endostatin protein are provided as well as methods of using the protein oligomer compositions to disrupt tubule formation and inhibit tumorigenesis. The compositions of the present invention constitute a new class of scatter factors and specifically include endostatin protein dimers and trimers, and optionally include metal ions such as zinc.

L'invention concerne des compositions à base d'oligomères protéiniques renfermant la protéine endostatine, ainsi que des procédés relatifs à l'utilisation desdites compositions, pour interrompre la formation de tubules et inhiber la tumorigenèse. Ces compositions représentent une nouvelle classe de facteurs de dispersion et comprennent spécifiquement les dimères et les trimères de la protéine endostatine, s'étendant éventuellement à des ions métalliques du type zinc.

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