Protein p53 fragments and their uses in detecting and...

Details Protein p53 fragments and their uses in detecting and... Protein p53 fragments and their uses in detecting and...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/82 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2148274

A p53 protein fragment peptide specifically reacting with antibodies to p53 in the body fluids of cancer patients or precarcinomatous individuals. The peptide is preferably included in amino acid sequence 1-112 or 350-393 of protein p53, and may be used for detecting or monitoring diseased conditions, particularly carcinous conditions.

2148274 9410306 Peptide, fragment de la protéine p53, présentant une réaction spécifique vis-à-vis d'anticorps anti-p53 présents dans les fluides biologiques de patients atteints d'un cancer ou pré-cancéreux. Préférentiellement, ce peptide est compris dans la séquence des amino-acides 1 à 112 ou dans la séquence 350 à 393 de la protéine p53. Il peut être utilisé pour la détection ou le suivi d'états pathologiques, en particulier d'états cancéreux.

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