Protein particles for therapeutic and diagnostic use

Details Protein particles for therapeutic and diagnostic use Protein particles for therapeutic and diagnostic use

A - Human Necessities

61

K

A61K 47/42 (2006.01) A61K 9/10 (2006.01) A61K 9/16 (2006.01) A61K 9/51 (2006.01) A61K 31/70 (2006.01) A61K 38/36 (2006.01) A61K 38/38 (2006.01) A61K 45/00 (2006.01) A61K 47/30 (2006.01) A61K 47/44 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/08 (2006.01)

Patent

CA 2220895

Albumin particles in the nanometer and micrometer size range in an aqueous suspension are rendered stable against resolubilization without the aid of a cross-linking agent and without denaturation, by the incorporation of a stabilizing agent in the particle composition. Stabilizing agents disclosed include reducing agents, oxidizing agents, hydrogen-accepting molecules, high molecular weight polymers, and sulfur-containing ring compounds. Also disclosed are fibrinogen-coated particles, cross-linked or non-cross-linked, and their use as co-aggregants with platelets and with themselves for purposes of shortening bleeding time and enhancing the effect of thrombin.

On stabilise vis-à-vis de la resolubilisation, des particules d'albumine de l'ordre du nanomètre et du micromètre dans une suspension aqueuse sans utiliser d'agent de réticulation et sans dénaturation, en incorporant un agent de stabilisation à la composition particulaire. Les agents de stabilisation selon l'invention sont, entre autres, des agents de réduction, des agents d'oxydation, des molécules acceptant l'hydrogène, des polymères de masse molaire élevée et des composés cycliques contenant du soufre. L'invention porte également sur des particules enrobées de fibrinogène, réticulées ou non, et sur leur utilisation en tant qu'agents de co-agrégation avec les plaquettes et eux-mêmes pour réduire le temps de saignement et amplifier l'action de la thrombine.

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