Protein phosphorylation in c-src signaling pathways

Details Protein phosphorylation in c-src signaling pathways Protein phosphorylation in c-src signaling pathways

C - Chemistry, Metallurgy

12

Q

C12Q 1/48 (2006.01) C07K 7/00 (2006.01) C07K 16/00 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2556019

The invention discloses 102 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of c-Src kinase, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/ Scaffold proteins, Actin Binding proteins, Cytoskeletal proteins, G protein/ GTPase Activating protein/Guanine Nucleotide Exchange Factor proteins, Helicases, RNA Binding proteins, Transcription/Translation Factor or Initiation Complex proteins, Cellular Metabolism Enzymes, and Vesicle proteins.

L'invention concerne 102 nouveaux sites de phosphorylation identifiés dans des protéines et des voies de transduction de signal en aval de la kinase c-Src. L'invention concerne également des anticorps spécifiques des sites de phosphorylation et des peptides étiquetés à isotope lourd (peptides AQUA) utilisés dans la détection et la quantification sélective de ces protéines/sites phosphorylé(e)s. L'invention concerne encore des procédés d'utilisation de ces réactifs. Parmi les sites de phosphorylation identifiés se trouvent des sites apparaissant dans les types de protéines suivants : les protéines adaptatrices/d'échafaudage, les protéines cytosquelettiques, les protéines G/les protéines d'activation de la GTPase/les protéines du facteur d'échange nucléotidique de la guanine, les hélicases, les protéines de liaison à l'ARN, les protéines de complexe d'initiation ou de facteur de transcription/translation, les enzymes du métabolisme cellulaire et les protéines vésiculaires.

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