C - Chemistry – Metallurgy – 40 – B
Patent
C - Chemistry, Metallurgy
40
B
C40B 40/08 (2006.01) A61K 45/00 (2006.01) C07K 1/04 (2006.01) C07K 16/00 (2006.01) C07K 19/00 (2006.01) C12N 15/10 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) C40B 30/00 (2006.01) C40B 40/02 (2006.01) C40B 50/06 (2006.01)
Patent
CA 2229043
The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.
La présente invention se rapporte à des séquences d'ADN synthétique qui codent une ou plusieurs collections de protéines/(poly)peptides homologues, et à des procédés de génération et d'application des banques de ces séquences d'ADN. L'invention se rapporte notamment à la préparation d'une banque de gènes d'anticorps humains à l'aide de séquences consensus synthétiques qui couvrent le répertoire structural d'anticorps codés dans le génome humain. L'invention se rapporte en outre à l'utilisation d'un gène d'anticorps consensus unique servant de structure universelle pour des banques d'anticorps extrêmement diverses.
Ge Liming
Knappik Achim
Moroney Simon
Pack Peter
Pluckthun Andreas
Morphosys Gesellschaft Fur Proteinoptimierung Mbh
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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