Protein polyligands joined to a stable protein core

Details Protein polyligands joined to a stable protein core Protein polyligands joined to a stable protein core

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/52 (2006.01) C07K 14/55 (2006.01) C07K 14/575 (2006.01) C07K 16/00 (2006.01) C07K 19/00 (2006.01) C12N 15/13 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2090105

2090105 9203569 PCTABS00011 Stable polyligands are provided by preparing fused proteins, where the fused protein comprises a ligand at one terminus and a subunit or a multimeric unit protein at the other terminus, where the fused protein is able to assemble to provide a polyligand. The polyligands find use in modulating physiological processes by inhibiting ligand induced signal transduction by surface membrane protein receptors and/or in the case of µ chain use, by complement mediated killing or any other effector functions. The molecule may be composed solely, of human components to avoid an immune response by the recipient.

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