Protein product for treatment of infectious diseases and...

A - Human Necessities – 61 – K

Patent

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A61K 38/17 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2681828

The inventors have found that CD6, a member of the superfamily Scavenger Receptor Cysteine-Rich (SRCR) expressed in human lymphocites binds to Gram-positive and Gram-negative bacterias, and to other microbial structures. Therefore, the product CD6 is useful for manufacturing a medicine for therapeutic and/or preventive treatment of an infectious disease, or an inflammatory process related with an infectious disease, or an inflammatory process related with the presence of a product derived from an infectious agent, in a mammal including a human. Examples of such inflammatory processes are systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis and septic shock.

Les inventeurs ont découvert que CD6, un membre de la super-famille Scavenger Receptor Cysteine-Rich (SRCR) exprimé dans les lymphocytes humains, se fixe aux bactéries gram positif et gram négatif, ainsi qu'à d'autres structures microbiennes. Par conséquent, le produit CD6 est utile pour la fabrication d'un médicament destiné au traitement thérapeutique et/ou préventif d'une maladie infectieuse, d'un processus inflammatoire lié à une maladie infectieuse ou d'un processus inflammatoire lié à la présence d'un produit dérivé d'un agent infectieux, chez un mammifère, y compris un humain. Des exemples de ces processus inflammatoires sont le syndrome de réponse inflammatoire systémique (SIRS), le sepsis, le sepsis sévère et le choc septique.

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